Activation of Cell Cycle Arrest and Apoptosis by the Proto-Oncogene Pim-2
نویسندگان
چکیده
منابع مشابه
Activation of Cell Cycle Arrest and Apoptosis by the Proto-Oncogene Pim-2
Potent survival effects have been ascribed to the serine/threonine kinase proto-oncogene PIM-2. Elevated levels of PIM-2 are associated with various malignancies. In human cells, a single Pim-2 transcript gives rise mainly to two protein isoforms (34, 41 kDa) that share an identical catalytic site but differ at their N-terminus, due to in-frame alternative translation initiation sites. In this ...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0034736